top of page


  • Bravo, C. P.#, Krukowski, K.#, Barker, S.#, Wang, C., Li, Y., Fan, L., Vázquez-Rosa, E., Shin, M.-K.,
    Wong, M. Y., McCullough, L.D., Kitagawa, R. S., Choi, H.A, Cacace, A., Sinha, S., Pieper, A. A., Rosi,
    S.*, Chen, X.*, Gan, L*. Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain
    injury. (*co-corresponding author). Mol Neurodeg. In Press.

  • Li Y, Munoz-Mayorga D#, Nie Y#, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L*, Chen X*. Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK. (*co-corresponding author) Cell Metab. 2024 Apr 16:S1550-4131(24)00118-9. doi: 10.1016/j.cmet.2024.03.014. Epub ahead of print. PMID: 38657612.

  • Li Y, Chang P, Sankaran S, Jang H, Nie Y, Zeng A, Hussain S, Wu JY, Chen X, Shi L. Bioorthogonal Stimulated Raman Scattering Imaging Uncovers Lipid Metabolic Dynamics in Drosophila Brain During Aging. GEN Biotechnol. 2023 Jun 1;2(3):247-261. doi: 10.1089/genbio.2023.0017. Epub 2023 Jun 19. PMID: 37363411; PMCID: PMC10286263.

  • Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui JD, Chen X, Hui E. CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis. J Exp Med. 2023 Jul 3;220(7). doi: 10.1084/jem.20221391. Epub 2023 Apr 12. PubMed PMID: 37042938; PubMed Central PMCID: PMC10103642.

  • Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 May 24;43(21):3970-3984. doi: 10.1523/JNEUROSCI.1878-22.2023. Epub 2023 Apr 5. PMID: 37019623; PMCID: PMC10219035.

  • Ojeda-Juárez, D., Lawrence, J. A., Soldau, K., Pizzo, D. P., Wheeler, E., Aguilar-Calvo, P., Khuu, H., Chen, J., Malik, A., Funk, G., Nam, P., Sanchez, H., Geschwind, M. D., Wu, C., Yeo, G. W., Chen,  X., Patrick, G. N., Sigurdson, C. J. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. (2022) Jul 26;172:105834. doi: 10.1016/j.nbd.2022.105834. PMID: 35905927.

  • Chen, X.*, Calandrelli, R., Girardini, J., Yan, Z.,  Tan, Z., Xu, X., Hiniker, A., Zhong, S.* "PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms." (*co-corresponding author). Cell Metab. 34(5), P651 (2022). 

  • Tracy, T.*, Madero-Pérez, J.*, Swaney, D.*, Chang,T., Moritz, M., Konrad, C., Ward, M., Stevenson, E., Hüttenhain, R., Kauwe, G., Mercedes, M., Sweetland-Martin, L., Chen, X., Mok, S.-A., Telpoukhovskaia, M., Min, S.-W., Wang, C., Sohn, P. D., Martin, J., Zhou, Y., Manfredi, G., Coppola, G., Krogan, N. J., Geschwind, D. H. and Gan, L. “Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative disease.” Cell. 185, 1–17, Feb 17, 2022.

  • Caballero, B., Bourdenx, M., Martin,E.L., Diaz, A., Sohn, P., Chen, X., Wang, C., Juste, Y., Wegmann, S., Patel, B., Young, Z., Kuo, S. Y., Rodriguez-Navarro, J.A., Shao, H., López, M., Karch, C., Goate, A., Gestwicki, J., Hyman, B., Gan, L. and Cuervo, A.M. “Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.” Nat. Commun. 12, 2238 (2021).

  • Sundermann, E.E., Panizzon, M.S., Chen, X., Andrews, M., Galasko, D., Banks, S.J., Alzheimer’s Disease Neuroimaging Initiative. Sex differences in Alzheimer's-related Tau biomarkers and a mediating effect of testosterone. Biol. Sex. Differ. 2020 Jun 19;11(1):33.


  • Chakrabortya, A., Tapryala, N., Venkovaa, T., Mitrab, J., Vasquezb, V., Sarkerc, A. H., Duarte-Silvad, S., Huai, W., Ashizawag, T., Ghosh, G., Macield, P., Sarkarh, P.S., Hegdeb, M. L.,  Chen, X., and Hazra, T. K.* "Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis." Proc Natl Acad Sci. 2020 Mar 23. pii: 201917280. doi: 10.1073/pnas.1917280117. 

  • Chen, X.*,Wang, C., Li, Y., Tang, Mok, S.-A., Tsai, R. M., Rojas, J. C., Karydas, A, Miller, B. L., Boxer, A. L., Gestwicki, J. E., Cuervo, A.M., Arkin, M. and Gan, L.* “Promoting Tau Secretion and Propagation by Hyperactive p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy.” (*co-corresponding author) Mol Neurodeg. 15, 2 (2020) doi:10.1186/s13024-019-0354-0

  • Chen X, Gan L. An exercise-induced messenger boosts memory in Alzheimer's disease. Nat Med. 2019 Jan;25(1):20-21. doi: 10.1038/s41591-018-0311-4. PubMed PMID: 30617321.

  • Wang C, Telpoukhovskaia MA, Bahr BA, Chen X*, Gan L*. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. (*co-corresponding author) Curr Opin Neurobiol. 2018 Feb;48:52-58. doi: 10.1016/j.conb.2017.09.005. Epub 2017 Oct 10. Review. PubMed PMID: 29028540.

  • Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L.Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 Oct 10;9(4):1221-1233. doi: 10.1016/j.stemcr.2017.08.019. Epub 2017 Sep 28. PubMed PMID: 28966121; PubMed Central PMCID: PMC5639430.

  • Chen, X., Reichert, C. M., Gan, L. “Molecular pathways in Alzheimer’s disease and cognitive function: new insights into pathobiology of tau.” Book Chapter in: Lazarov, O. (Ed.) Genes, Environment and Alzheimer’s Disease. Oxford: Academic Press, 2016, pp. 135 - 168.

  • Min SW*, Chen X*, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. (*co-first author) Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. PubMed PMID: 26390242; PubMed Central PMCID: PMC4598295.

  • Chen X, Peterson J, Nachman RJ, Ganetzky B. Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila. Fly (Austin). 2012 Oct-Dec;6(4):290-7. doi: 10.4161/fly.21534. Epub 2012 Aug 13. PubMed PMID: 22885328; PubMed Central PMCID: PMC3519664.

  • Chen X, Ganetzky B. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012 Feb 20;196(4):529-43. doi: 10.1083/jcb.201109044. Epub 2012 Feb 13. PubMed PMID: 22331845; PubMed Central PMCID: PMC3283997.

bottom of page