Publications

  • Chakrabortya, A., Tapryala, N., Venkovaa, T., Mitrab, J., Vasquezb, V., Sarkerc, A. H., Duarte-Silvad, S., Huai, W., Ashizawag, T., Ghosh, G., Macield, P., Sarkarh, P.S., Hegdeb, M. L.,  Chen, X., and Hazra, T. K.* "Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis." Proc Natl Acad Sci. 2020 Mar 23. pii: 201917280. doi: 10.1073/pnas.1917280117. 

  • Chen, X.*,Wang, C., Li, Y., Tang, Mok, S.-A., Tsai, R. M., Rojas, J. C., Karydas, A, Miller, B. L., Boxer, A. L., Gestwicki, J. E., Cuervo, A.M., Arkin, M. and Gan, L.* “Promoting Tau Secretion and Propagation by Hyperactive p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy.” (*co-corresponding author) Mol Neurodegeneration 15, 2 (2020) doi:10.1186/s13024-019-0354-0

  • Chen X, Gan L. An exercise-induced messenger boosts memory in Alzheimer's disease. Nat Med. 2019 Jan;25(1):20-21. doi: 10.1038/s41591-018-0311-4. PubMed PMID: 30617321.

  • Wang C, Telpoukhovskaia MA, Bahr BA, Chen X*, Gan L*. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. (*co-corresponding author) Curr Opin Neurobiol. 2018 Feb;48:52-58. doi: 10.1016/j.conb.2017.09.005. Epub 2017 Oct 10. Review. PubMed PMID: 29028540.

  • Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L.Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 Oct 10;9(4):1221-1233. doi: 10.1016/j.stemcr.2017.08.019. Epub 2017 Sep 28. PubMed PMID: 28966121; PubMed Central PMCID: PMC5639430.

  • Chen, X., Reichert, C. M., Gan, L. “Molecular pathways in Alzheimer’s disease and cognitive function: new insights into pathobiology of tau.” Book Chapter in: Lazarov, O. (Ed.) Genes, Environment and Alzheimer’s Disease. Oxford: Academic Press, 2016, pp. 135 - 168.

  • Min SW*, Chen X*, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. (*co-first author) Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. PubMed PMID: 26390242; PubMed Central PMCID: PMC4598295.

  • Chen X, Peterson J, Nachman RJ, Ganetzky B. Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila. Fly (Austin). 2012 Oct-Dec;6(4):290-7. doi: 10.4161/fly.21534. Epub 2012 Aug 13. PubMed PMID: 22885328; PubMed Central PMCID: PMC3519664.

  • Chen X, Ganetzky B. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012 Feb 20;196(4):529-43. doi: 10.1083/jcb.201109044. Epub 2012 Feb 13. PubMed PMID: 22331845; PubMed Central PMCID: PMC3283997.

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© 2020 by Xu Chen Lab @ UCSD