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Publications

  • Dion, W.†, Tao, Y.†, Chambers, M., Zhao, S., Arbuckle, R. K., Sun, M., Kubra, S., Nie, Y., Ye, M., Larsen, M. B., Camarco, D., Ickes, E., DuPont, C., Wang, H., Wang, B., Liu, S., Pi, S., Chen, B. B., Chen, Y.*, Chen, X.*, Zhu, B.* SON-dependent nuclear speckle rehabilitation alleviates proteinopathies. (†equal contribution; *co-corresponding author) Nat Comm. 16, 7065 (2025). https://doi.org/10.1038/s41467-025-62242-7

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  • Jati S, Munoz-Mayorga D†, Shahabi S†, Tang K, Tao Y, Dickson DW, Litvan I, Ghosh G*, Mahata SK*, Chen X. Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine-Alpha-Adrenergic Receptor Signaling. (†equal contribution; *co-corresponding author) Nat Comm. 16, 4703 (2025). https://doi.org/10.1038/s41467-025-59682-6

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  • Masubuchi T, Chen L, Marcel N, Wen GA, Caron C, Zhang J, Zhao Y, Morris GP, Chen X, Hedrick SM, Lu LF, Wu C, Zou Z, Bui JD, Hui E. Functional differences between rodent and human PD-1 linked to evolutionary divergence. Sci Immunol. 2025;10(103):eads6295. Epub 20250103. doi: 10.1126/sciimmunol.ads6295. PubMed PMID: 39752535. ​

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  • Parra Bravo C†, Krukowski K†, Barker S†, Wang C, Li Y, Fan L, Vázquez-Rosa E, Shin MK, Wong MY, McCullough LD, Kitagawa RS, Choi HA, Cacace A, Sinha SC, Pieper AA, Rosi S*, Chen X*, Gan L*. Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury. Mol Neurodegener. 2024 Jun 24;19(1):51. doi: 10.1186/s13024-024-00733-9. PMID: 38915105; PMCID: PMC11197196. (†equal contribution; *co-corresponding author). Mol Neurodeg. 19, 51. 10.1186/s13024-024-00733-9.

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  • Li Y, Munoz-Mayorga D†, Nie Y†, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L*, Chen X*. Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK. (†equal contribution; *co-corresponding author) Cell Metab. 2024 Apr 16:S1550-4131(24)00118-9. doi: 10.1016/j.cmet.2024.03.014. Epub ahead of print. PMID: 38657612.

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  • Li Y, Chang P, Sankaran S, Jang H, Nie Y, Zeng A, Hussain S, Wu JY, Chen X, Shi L. Bioorthogonal Stimulated Raman Scattering Imaging Uncovers Lipid Metabolic Dynamics in Drosophila Brain During Aging. GEN Biotechnol. 2023 Jun 1;2(3):247-261. doi: 10.1089/genbio.2023.0017. Epub 2023 Jun 19. PMID: 37363411; PMCID: PMC10286263.

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  • Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui JD, Chen X, Hui E. CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis. J Exp Med. 2023 Jul 3;220(7). doi: 10.1084/jem.20221391. Epub 2023 Apr 12. PubMed PMID: 37042938; PubMed Central PMCID: PMC10103642.

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  • Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 May 24;43(21):3970-3984. doi: 10.1523/JNEUROSCI.1878-22.2023. Epub 2023 Apr 5. PMID: 37019623; PMCID: PMC10219035.

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  • Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 Oct 1;172:105834. doi: 10.1016/j.nbd.2022.105834. Epub 2022 Jul 26. PMID: 35905927; PMCID: PMC10080886.

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  • Chen X*, Calandrelli R, Girardini J, Yan Z, Tan Z, Xu X, Hiniker A, Zhong S*. PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms. (*co-corresponding author) Cell Metab. 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008. PMID: 35508105; PMCID: PMC9531314. 

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  • Tracy TE*, Madero-Pérez J*, Swaney DL*, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. (*equal contribution) Cell. 2022 Feb 17;185(4):712-728.e14. doi: 10.1016/j.cell.2021.12.041. Epub 2022 Jan 20. PMID: 35063084; PMCID: PMC8857049.

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  • Caballero B*, Bourdenx M*, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate AM, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. (*equal contribution) Nat Commun. 2021 Apr 14;12(1):2238. doi: 10.1038/s41467-021-22501-9. PMID: 33854069; PMCID: PMC8047017.

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  • Sundermann EE, Panizzon MS, Chen X, Andrews M, Galasko D, Banks SJ; Alzheimer’s Disease Neuroimaging Initiative. Sex differences in Alzheimer's-related Tau biomarkers and a mediating effect of testosterone. Biol Sex Differ. 2020 Jun 19;11(1):33. doi: 10.1186/s13293-020-00310-x. PMID: 32560743; PMCID: PMC7304096.

 

  • Chakraborty A, Tapryal N, Venkova T, Mitra J, Vasquez V, Sarker AH, Duarte-Silva S, Huai W, Ashizawa T, Ghosh G, Maciel P, Sarkar PS, Hegde ML, Chen X, Hazra TK. Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis. Proc Natl Acad Sci  U S A. 2020 Apr 7;117(14):8154-8165. doi: 10.1073/pnas.1917280117. Epub 2020 Mar 23. PMID: 32205441; PMCID: PMC7148577.

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  • Chen X*, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L*. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. (*co-corresponding author) Mol Neurodegener. 2020 Jan 6;15(1):2. doi: 10.1186/s13024-019-0354-0. PMID: 31906970; PMCID: PMC6945522.

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  • Chen X, Gan L. An exercise-induced messenger boosts memory in Alzheimer's disease. Nat Med. 2019 Jan;25(1):20-21. doi: 10.1038/s41591-018-0311-4. PMID: 30617321.

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  • Wang C, Telpoukhovskaia MA, Bahr BA, Chen X*, Gan L*. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. (*co-corresponding author) Curr Opin Neurobiol. 2018 Feb;48:52-58. doi: 10.1016/j.conb.2017.09.005. Epub 2017 Oct 10. PMID: 29028540.

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  • Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 2017 Oct 10;9(4):1221-1233. doi: 10.1016/j.stemcr.2017.08.019. Epub 2017 Sep 28. PMID: 28966121; PMCID: PMC5639430.

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  • Chen X, Reichert CM, Gan L. “Molecular pathways in Alzheimer’s disease and cognitive function: new insights into pathobiology of tau.” Book Chapter in: Lazarov, O. (Ed.) Genes, Environment and Alzheimer’s Disease. Oxford: Academic Press, 2016, pp. 135 - 168.

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  • Min SW*, Chen X*, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. (*equal contribution) Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. PMID: 26390242; PMCID: PMC4598295.

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  • Chen X, Peterson J, Nachman RJ, Ganetzky B. Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila. Fly (Austin). 2012 Oct-Dec;6(4):290-7. doi: 10.4161/fly.21534. Epub 2012 Aug 13. PMID: 22885328; PMCID: PMC3519664.

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  • Chen X, Ganetzky B. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012 Feb 20;196(4):529-43. doi: 10.1083/jcb.201109044. Epub 2012 Feb 13. PMID: 22331845; PMCID: PMC3283997.

© 2025 by Xu Chen Lab @ UCSD

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